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Platelet rich plasma (PRP) application is a successful catalyst in the healing process for wide varieties of conditions. PRP was first developed in the 1970s and first used in an open heart surgery procedure.
Activated platelets release granules that are involved in processes of tissue regeneration, epithelialization, proliferation and differentiation of osteoblasts, and in synthesis of collagen and extracellular matrix of connective tissue.
Use of PRP in Non-healing skin Ulcers
Any wound goes through stages of acute inflammation, increased mitotic activity and finally orderly repair. Practically, a chronic wound is the one which has failed to heal within 3 months.
Fibrin membranes are very useful for treating chronic diabetic non healing ulcers, and pressure sores. Use of fibrin membranes in such cases can prepare the wound for skin grafting earlier, reducing the time for total healing.
PRP Product to be used
Concentrated PRF preparations ( typically 7-10 times concentration of platelets in fibrin clot) are used in these conditions. Quantity required varies depending on area of wound.
What to expect
Initially after injection slight discomfort or increase in pain is expected for first 1-3 days as injected platelets give some inflammatory response. It subsides rapidly and may require mild analgesics initially.
The injected platelets release growth factors over next one week and rapid reversal of original symptoms and good regeneration is expected in 1-2 weeks.